Ozone therapy for the complementary treatment of diabetic foot ulcer: integrative review
DOI:
https://doi.org/10.17267/2317-3378rec.2022.e4647Keywords:
Ozone therapy, Diabetic Foot, Complementary therapiesAbstract
OBJECTIVE: To analyze the knowledge about the use of ozone therapy as a complementary treatment for diabetic foot ulcers. METHODS: This is an integrative literature review in which the search for articles took place in the Latin American and Caribbean Health Sciences Literature (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) databases. In addition to these, the Scientific Electronic Library Online (SciELO), National Medical Sciences Information Center of Cuba (CUMED) databases, and the portal for the dissemination of Hispanic scientific production, Dialnet, were also used. RESULTS: The research analyzed a sample of seven articles. They were organized into thematic categories according to the content that emerged in the publications: ozone therapy application methods in the treatment of diabetic foot ulcers, the benefits of ozone therapy for diabetic foot ulcers, and limitations of ozone therapy use. FINAL CONSIDERATIONS: From the discursive analysis of scientific articles, it is hoped that the results of this study become an incentive tool for the development of further research on the use of ozone therapy as a complementary for diabetic foot ulcers.
Downloads
References
(1) International Diabetes Federation. IDF Diabetes Atlas [Internet]. 9th. ed. Belgium: International Diabetes Federation; 2019. Available from: https://diabetesatlas.org/atlas/ninth-edition/
(2) Moraes HAB, Mengue SS, Molina MCB, Cade NV. Factors associated with glycemic control in a sample of individuals with Diabetes Mellitus taken from the Longitudinal Study of Adult Health, Brazil, 2008-2010. Epidemiol. Serv. Saúde. 2020;29(3):e2018500. https://doi.org/10.5123/S1679-49742020000300017
(3) Liu J, Zhang P, Tian J, Li L, Li J, Tian JH, et al. Ozone therapy for treating foot ulcers in people with diabetes. Cochrane Database Syst Rev. 2015;2015(10):CD008474. https://doi.org/10.1002/14651858.cd008474.pub2
(4) Almeida SA, Silveira MM, Espírito Santo PF, Pereira RC, Salomé GM. Assessment of the quality of life of patients with diabetes mellitus and foot ulcers. Rev Bras Cir Plást. 2013;28(1):142-46. https://doi.org/10.1590/S1983-51752013000100024
(5) Ministério da Saúde (Brasil), Secretaria de Atenção à Saúde, Departamento de Atenção Básica. Manual do pé diabético: estratégias para o cuidado da pessoa com doença crônica [Internet]. Brasília: Ministério da Saúde; 2016. Available from: https://aps.saude.gov.br/biblioteca/visualizar/MTMzNQ
(6) Oliveira JEP, Foss-Freitas MC, Montenegro Junior RM, Vencio S, organizadores. Diretrizes da Sociedade Brasileira de Diabetes 2017-2018 [Internet]. São Paulo: Editora Clannad; 2017. Available from: https://edisciplinas.usp.br/pluginfile.php/4925460/mod_resource/content/1/diretrizes-sbd-2017-2018.pdf
(7) International Working Group on the Diabetic Foot. IWGDF Guidelines on the prevention and management of diabetic foot disease [Internet]. 2019. Available from: https://onlinelibrary.wiley.com/doi/epdf/10.1002/dmrr.3266
(8) Thomazelli FCS, Machado CB, Dolçan KS. Análise do risco de pé diabético em um ambulatório interdisciplinar de diabetes. Rev. AMRIGS [Internet]. 2015;59(1):10-14. Available from: https://web.archive.org/web/20180412025010id_/http://www.amrigs.com.br/revista/59-01/02_1436_Revista%20AMRIGS.pdf
(9) Izadi M, Kheirjou R, Mohammadpour R, Aliyoldashi MH, Moghadam SJ, Khorvash F, et al. Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing. Diabetes Metab Syndr. 2019;13(1):822-25. https://doi.org/10.1016/j.dsx.2018.11.060
(10) Tanaka RY, Pheula LYT, Monteiro DR, Souza TC. The use of ozone therapy in the treatment of diabetic foot: integrative review. Res., Soc. Dev. 2020;9(12):e44791211319. http://dx.doi.org/10.33448/rsd-v9i12.11319
(11) Cardoso CC, Dias Filho E, Pichara NL, Campos EGC, Pereira MA, Fiorini JE. Ozonoterapia como tratamento adjuvante na ferida de pé diabético. Rev Méd Minas Gerais [Internet]. 2010;20:442-45. Available from: http://www.rmmg.org/artigo/detalhes/1184
(12) Morette DA. Principais aplicações terapêuticas da ozonioterapia [final paper] [Internet]. São Paulo: Universidade Estadual Paulista Júlio de Mesquita Filho; 2011. Available from: https://repositorio.unesp.br/handle/11449/120089
(13) Oliveira MSG, Silva KR, Melo CSB, Lemos ACM. Ozone therapy in pressure injuries as an alternative to nursing care. Res., Soc. Dev. 2021;10(3):e58910313777. https://doi.org/10.33448/rsd-v10i3.13777
(14) Ministério da Saúde (Brasil), Secretaria de Atenção à Saúde, Departamento de Atenção Básica. Política nacional de práticas integrativas e complementares no SUS: atitude de ampliação de acesso [Internet]. 2nd. ed. Brasília: Ministério da Saúde; 2018. Available from: https://bvsms.saude.gov.br/bvs/publicacoes/politica_praticas_integrativas_complementares_sus_2ed_1_reimp.pdf
(15) Conselho Federal de Enfermagem. Parecer normativo nº 001/2020 de 20 de fevereiro de 2020. Regulamenta a ozonioterapia como prática do enfermeiro no Brasil [Internet]. Available from: http://www.cofen.gov.br/parecer-normativo-no-001-2020_77357.html
(16) Souza MT, Silva MD, Carvalho R. Integrative review: what is it? How to do it?. Einstein. 2010;8(1):102-6. https://doi.org/10.1590/s1679-45082010rw1134
(17) Ercole FF, Melo LS, Alcoforado CLGC. Integrative Review versus Systematic Review. Rev Min Enferm. 2014;18(1):12-14. https://doi.org/10.5935/1415-2762.20140001
(18) Galvão TF, Pansani TSA, Harrad D. Principais itens para relatar revisões sistemáticas e meta-análises: a recomendação PRISMA. Epidemiol. Serv. Saúde [Internet]. 2015;24(2):335-42. Available from: https://www.scielo.br/j/ress/a/TL99XM6YPx3Z4rxn5WmCNCF/?lang=pt#
(19) Zhang J, Guan M, Xie C, Luo X, Zhang Q, Xue Y. Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers. Oxid Med Cell Longev. 2014;2014:273475. https://doi.org/10.1155/2014/273475
(20) Faraji N, Goli R, Choobianzali B, Bahrami S, Sadeghian A, Sepehrnia N. Ozone therapy as an alternative method for the treatment of diabetic foot ulcer: a case report. J Med Case Rep. 2021;15(1):234. https://doi.org/10.1186/s13256-021-02829-y
(21) Martínez AF, Martínez AF, Pérez CV, Leonard DP, López AAA. Evolution of diabetic foot ulcers with the mixed treatment of Heberprot-P® and ozone therapy. Rev. Cuba Angiol. Cir. Vasc [Internet]. 2019;20(1). Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1682-00372019000100003
(22) Arizpe HJM. Tratamiento de ulcera en pie diabético con Ozono de sonda fría. Reporte de un caso. Revista Española de Ozonoterapia [Internet]. 2016;6(1):217-22. Available from: http://www.xn--revistaespaoladeozonoterapia-7xc.es/index.php/reo/article/view/99
(23) Marchesini BF, Ribeiro SB. Effect of ozonotherapy on wound healing. Fisioter Bras. 2020;21(3):281-8. https://doi.org/10.33233/fb.v21i3.2931
(24) Duarte HA, Carretero JH, Peña YA, Valcárcel JRG, Concepción DR, Carbonell VGJ. Advantages of the ozone therapy in neuro-infective diabetic foot patients. Rev. Cubana Angiol Cir Vasc [Internet]. 2014;15(1):12-21. Available from: https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDREVISTA=273&IDARTICULO=48416&IDPUBLICACION=4972
(25) Bladinieres-Camara JE, Uhthoff-Brito S, Alcalá-Duran R, Anaya-Prado R, Lara-Ramírez EE. Neuroischemic diabetic foot treated with ozone. Consequences of treatment. Cir Gen. 2015;37(1-2):44-48. https://dx.doi.org/10.35366/63554
(26) Oliveira JTC. Revisão sistemática de literatura sobre o uso terapêutico do ozônio em feridas [masters dissertation]. São Paulo: Universidade de São Paulo; 2007. https://doi.org/10.11606/D.7.2007.tde-20122007-094050
(27) Lescura ICPS, Bega A. Use of direct ozone in a bag and ozonized oil in chronic lesions in the lower limbs of diabetics. Rev. Ibero-Am. Pod. 2020;2(3):260-69. https://doi.org/10.36271/iajp.v2i3.46
(28) Pérez EJM, Callis GP, Valdenebro LR, Sorribe RF. Cost-benefit of the treatment with Heberprot-P® in patients with diabetic foot. MediSan [Internet]. 2018;22(3):223-33. Available from: https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=78913
(29) Clavo B, Santana-Rodriguez N. Are we ready for a medical ozone challenge? J Exp Integr Med [Internet]. 2012;2(3):189-91. Available from: https://www.bibliomed.org/?mno=20999
(30) Re L, Malcangi G, Martinez-Sanchez G. Medical ozone is now ready for a scientific challenge: current status and future perspectives. J Exp Integr Med. 2012;2(3):193-96. Available from: https://www.researchgate.net/publication/274584833_Medical_ozone_is_now_ready_for_a_scientific_challenge_Current_status_and_future_perspectives
(31) Solovastru LG, Stîncanu A, Ascentii A, Capparé G, Mattana P, Vata D. Randomized, controlled study of innovative spray formulation containing ozonated oil and ?-bisabolol in the topical treatment of chronic venous leg ulcers. Adv Skin Wound Care. 2015;28(9):406-9. https://doi.org/10.1097/01.asw.0000470155.29821.ed
(32) Mota MR, Ribeiro WS, Dantas RAE, Silva AO, Alves AR, Cavalcante TA, et al. Influence of ozone therapy on the healing of diabetic foot ulcers. Braz. J. of Develop. 2020;6(8):58274-58286. https://doi.org/10.34117/bjdv6n8-294
(33) Baldizón MRL. Uso combinado de ozonoterapia y fibrina autóloga rica en plaquetas y leucocitos (L-PRF) en el tratamiento de úlceras cutáneas. Revista Española de Ozonoterapia [Internet]. 2017;7(1):59-65. Available from: http://www.xn--revistaespaoladeozonoterapia-7xc.es/index.php/reo/article/view/113
(34) Zhang P, Yang K, Tian J, Ma B, Liu Y, Li J, et al. Ozone therapy for treating diabetic foot ulcers. Coch Datab System Rev. 2010;4:CD008474. https://doi.org/10.1002/14651858.CD008474
(35) Kuroda K, Azuma K, Mori T, Kawamoto K, Murahata Y, Tsuka T, et al. The safety and anti-tumor effects of ozonated water in vivo. International Journal of Molecular Sciences. 2015;16(10):25108-25120. https://doi.org/10.3390/ijms161025108
(36) Schwartz A, Martínez-Sánchez G. La Ozonoterapia y su fundamentación científica. Revista Española de Ozonoterapia [Internet]. 2012;2(1):163-198. Available from: http://xn--revistaespaoladeozonoterapia-7xc.es/index.php/reo/article/view/23
(37) Leonardi M. Possibilities of Medical Ozone. Int J Ozone Therapy. 2013;12(2):131-32. Available from: https://www.wfoot.org/wp-content/uploads/2016/12/IJOT_12_2_ID81.pdf
(38) Fernández JLC, Falcón BA, Santana RL, Santiuste RL, Perez IW, Cairo CRN. Presentación de un caso de pie diabético neuro-infeccioso tratado con ozonoterapia. Revista CENIC Ciencias Biológicas [Internet]. 2015;46(2):195-202. Available from: https://revista.cnic.cu/index.php/RevBiol/article/view/89
(39) Wainstein J, Feldbrin Z, Boaz M, Harman-Boehm I. Efficacy of Ozone–Oxygen Therapy for the Treatment of Diabetic Foot Ulcers. Diabetes Technol Ther. 2011;13(12):1255-60. https://doi.org/10.1089/dia.2011.0018
(40) Barbosa DC, Ângelos JS, Macena GMJ, Magalhães FNO, Fonoff ET. Effects of ozone on the pain and disability in patients with failed back surgery syndrome. Rev Assoc Med Bras 2017;63(4):355-60. https://doi.org/10.1590/1806-9282.63.04.355
(41) Costa NT. Papel do fator de necrose tumoral alfa (TNF-alfa) no processo inflamatório, no estresse oxidativo e na atividade da doença em pacientes com artrite reumatoide e resistência à insulina [masters dissertation] [Internet]. Londrina: Universidade Estadual de Londrina; 2014. Available from: http://www.bibliotecadigital.uel.br/document/?code=vtls000197709
(42) International Scientific Committee of Ozone Therapy. Madrid Declaration on Ozone Therapy [Internet]. 3a. ed. Madrid; 2020. Available from: https://isco3.org/madrid-declaration-on-ozone-therapy-3rd-edition-isco3/
(43) Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017;7(3):212-19. https://doi.org/10.4103/2045-9912.215752
(44) Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res. 2006;37(4):425-35. https://doi.org/10.1016/j.arcmed.2005.08.006
(45) Biggers A, Seymour T. What is ozone therapy? Benefits and risks [Internet]. Medical News Today; 2020. Available from: https://www.medicalnewstoday.com/articles/320759
(46) Associação Brasileira de Ozonioterapia. Regulamentação Profissional em Ozonioterapia [Internet]. 2021. Available from: https://www.aboz.org.br/noticias/regulamentacao-da-ozonioterapia-no-brasil/151/
(47) Teuvov AA, Baziev AM, Lovpache ZN, Teunikova IS, Chudopal SM. Ozone Therapy in the Comprehensive Treatment of Diabetic Foot Syndrome. Biomed Pharmacol J. 2017;10(4):1871-78. https://doi.org/10.13005/bpj/1306
(48) Pinheiro EZ, Barbosa RSP. Ozoniotherapy action on diabetic foot ulcers. Revista Cathedral [Internet]. 2021;3(2):82-90. Available from: http://cathedral.ojs.galoa.com.br/index.php/cathedral/article/view/318
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Tatiana Costa Franco Miranda, Girleide Souza dos Santos, Joana de Novais Chaves, Rosana Freitas Azevedo
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
