Effect of aerobic training on depression and thyroid function in treated hypothyroid women

Authors

DOI:

https://doi.org/10.17267/2238-2704rpf.2023.e5254

Keywords:

Hypothyroidism, Depressive Symptoms, Exercise

Abstract

INTRODUCTION: Hypothyroidism is commonly associated with depression and a slowing in mental activity. OBJECTIVES: The current investigation aimed to investigate the effect of aerobic training on depression and thyroid function in treated hypothyroid females. METHODS AND MATERIALS: Thirty women diagnosed with primary hypothyroidism that was regulated and accompanied by mild to moderate levels of depression completed a 12-week randomized controlled exercise trial involving two equal groups: aerobic (n = 15) and control (n = 15) groups. The exercising group performed three sessions of aerobic exercise per week at low to moderate intensity for 12 consecutive weeks while the control group performed no exercise intervention during the same duration. At baseline and post-intervention, Beck Depression Inventory score (BDIS), thyroid stimulating hormone (TSH) and free thyroxin (T4) were assessed. RESULTS: The exercising group showed significant improvements in BDIS, TSH and free T4 compared to baseline (p < 0.05) with negligible change in the control group (p > 0.05). As compared to the control, all measured items differed significantly in favor to the aerobic training group. CONCLUSION: In women with treated hypothyroidism, aerobic training can minimize depressive symptoms and enhance thyroid function.

Downloads

Download data is not yet available.

References

(1) Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017;390(10101):1550-62. https://doi.org/10.1016/s0140-6736(17)30703-1

(2) Bereda G. Definition, Causes, Pathophysiology, and Management of Hypothyroidism. Mathews J Pharma Sci. 2023;7(1):14. https://doi.org/10.30654/MJPS.10014

(3) Chiovato L, Magri F, Carlé A. Hypothyroidism in Context: Where We've Been and Where We're Going. Adv Ther. 2019;36(suppl 2):47-58. https://doi.org/10.1007%2Fs12325-019-01080-8

(4) Tayde PS, Bhagwat NM, Sharma P, Sharma B, Dalwadi PP, Sonawane A, et al. Hypothyroidism and Depression: Are Cytokines the Link?. Indian J Endocrinol Metab. 2017;21(6):886-92. https://doi.org/10.4103%2Fijem.IJEM_265_17

(5) Whybrow PC, Prange AJ Jr, Treadway CR. Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement. Arch Gen Psychiatry. 1969;20(1):48-63. https://doi.org/10.1001/archpsyc.1969.01740130050004

(6) Cleare AJ, McGregor A, O'Keane V. Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression. Clin Endocrinol. 1995;43(6):713-9. https://doi.org/10.1111/j.1365-2265.1995.tb00540.x

(7) Ge JF, Xu YY, Qin G, Cheng JQ, Chen FH. Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway. Front Endocrinol. 2016;7:44. https://doi.org/10.3389/fendo.2016.00044

(8) Kotkowska Z, Strzelecki D. Depression and Autoimmune Hypothyroidism-Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines-A Systematic Review. Pharmaceuticals. 2022;15(4):391. https://doi.org/10.3390/ph15040391

(9) Iosifescu DV, Bolo NR, Nierenberg AA, Jensen JE, Fava M, Renshaw PF. Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder. Biol Psychiatry. 2008;63(12):1127-34. https://doi.org/10.1016/j.biopsych.2007.11.020

(10) Bauer M, Berman SM, Schlagenhauf F, Voytek B, Rasgon N, Mandelkern MA, et al. Regional cerebral glucose metabolism and anxiety symptoms in bipolar depression: effects of levothyroxine. Psychiatry Res. 2010;181(1):71-6. https://doi.org/10.1016/j.pscychresns.2009.07.001

(11) Zhou Y, Wang X, Zhao Y, Liu A, Zhao T, Zhang Y, et al. Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice. Front Cell Neurosci. 2017;10:307. https://doi.org/10.3389/fncel.2016.00307

(12) Bortolotto VC, Pinheiro FC, Araujo SM, Poetini MR, Bertolazi BS, Paula MT, et al. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. Eur J Pharmacol. 2018;822:78-84. https://doi.org/10.1016/j.ejphar.2018.01.017

(13) Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, et al. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014;24(12):1670-751. https://doi.org/10.1089/thy.2014.0028

(14) Sawka AM, Gerstein HC, Marriott MJ, MacQueen GM, Joffe RT. Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin Endocrinol Metab. 2003;88(10):4551-5. https://doi.org/10.1210/jc.2003-030139

(15) Bai S, Chen L, Zhao L. Research on the evolution of movement difficulty of competitive aerobics based on digital image processing. J Intell Fuzzy Syst. 2021. Available from: https://www.researchgate.net/publication/352050813_Research_on_the_evolution_of_movement_difficulty_of_competitive_aerobics_based_on_digital_image_processing

(16) Todorova V, Dolinsky B, Pasichna T. Improving the content of choreographic training in sports aerobics at the stage of specialized basic training. Science and Education. 2020;(1):60-5. https://doi.org/10.24195/2414-4665-2020-1-9

(17) Bansal N, Kotwal N, Kumar S. Aerobic vs Resistance Exercise—An Endocrine Perspective. J Med Acad. 2020;3(1):7-10. https://doi.org/10.5005/jp-journals-10070-0057

(18) Abbas MAM, El Badrey SM, ElDeeb AM, Sayed AM. Effect of aerobic exercises on the thyroid hormones in treated hypothyroid pregnant women. Adv Pharm Edu Res [Internet]. 2019;9(4):49-53. Available from: https://japer.in/article/effect-of-aerobic-exercises-on-the-thyroid-hormones-in-treated-hypothyroid-pregnant-women

(19) Askari J, Saberi-Kakhki A, Taheri H, Yassini SM. The Effect of Aerobic Exercise on Different Symptoms of Depression: An Investigation of Psychological Mechanisms of Stress and Coping. Open J Med Psychol. 2017;6(2):86-102. https://doi.org/10.4236/ojmp.2017.62007

(20) Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, et al. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003;13(1):3-126. https://doi.org/10.1089/105072503321086962

(21) Nuttall FQ. Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutr Today. 2015;50(3):117-28. https://doi.org/10.1097/nt.0000000000000092

(22) Svenaeus F. Diagnosing mental disorders and saving the normal. Med Health Care Philos. 2014;17(2):241-4. https://doi.org/10.1007/s11019-013-9529-6

(23) Wang YP, Gorenstein C. Psychometric properties of the Beck Depression Inventory-II: a comprehensive review. Braz J Psychiatry. 2013;35(4):416-31. https://doi.org/10.1590/1516-4446-2012-1048

(24) Beck AT, Steer RA, Brown GK. BDI-II, Beck Depression Inventory: Manual. San Antonio: TX Psychological Corporation; 1996.

(25) Fawzi MH, Fawzi MM, Abu-Hindi W. Arabic version of the Major Depression Inventory as a diagnostic tool: reliability and concurrent and discriminant validity. East Mediterr Health J. 2012;18(4):304-10. https://doi.org/10.26719/2012.18.4.304

(26) Bruce RA. Exercise testing of patients with coronary heart disease. Principles and normal standards for evaluation. Ann Clin Res. 1971;3(6):323-32. Cited: PMID: 5156892

(27) Bongers BC, Vries SI, Obeid J, van Buuren S, Helders PJM, Takken T. The Steep Ramp Test in Dutch white children and adolescents: age- and sex-related normative values. Phys Ther. 2013;93(11):1530-9. https://doi.org/10.2522/ptj.20120508

(28) Holtgrefe, K. Principles of aerobic exercises. In: Kisner C, Colby LA. Therapeutic exercise, Foundations and Techniques. 6th. ed. Philadelphia: F. A. Davis Company; 2012. p. 247-251.

(29) Bodegard J, Erikssen G, Bjørnholt JV, Gjesdal K, Liestøl K, Erikssen J. Reasons for terminating an exercise test provide independent prognostic information: 2014 apparently healthy men followed for 26 years. Eur Heart J. 2005;26(14):1394-401. https://doi.org/10.1093/eurheartj/ehi278

(30) Rani S, Maharana S, Metri KG, Bhargav H, Nagaratna R. Effect of yoga on depression in hypothyroidism: A pilot study. J Tradit Complement Med. 2021;11(4):375-80. https://doi.org/10.1016/j.jtcme.2021.01.001

(31) Rahman MH, Ali MY. The Relationships between Thyroid Hormones and the Brain Serotonin (5-HT) System and Mood: Of Synergy and Significance in the Adult Brain- A Review. Faridpur Med Coll J. 2015;9(2):98-101. https://doi.org/10.3329/fmcj.v9i2.25684

(32) Ezzat W, Abd-El Hamid MS. Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats. Journal of Affective Disorders Reports. 2021;6:100268. https://doi.org/10.1016/j.jadr.2021.100268

(33) Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-García JM, et al. Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity. Neuropsychopharmacology. 2017;42(2):512-23. https://doi.org/10.1038/npp.2016.134

(34) Sigwalt AR, Budde H, Helmich I, Glaser V, Ghisoni K, Lanza S, et al. Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression. Neuroscience. 2011;192:661-74. https://doi.org/10.1016/j.neuroscience.2011.05.075

(35) Wang X, Cai ZD, Jiang WT, Fang YY, Sun WX, Wang X. Systematic review and meta-analysis of the effects of exercise on depression in adolescents. Child Adolesc Psychiatry Ment Health. 2022;16(1):16. https://doi.org/10.1186/s13034-022-00453-2

(36) Rao UT, Noronha JA, Adiga K. Effect of aerobic exercises on depressive symptoms, anxiety, self-esteem, and quality of life among adults with depression. Clin Epidemiology Glob Health. 2020;8(4):1147-51. https://doi.org/10.1016/j.cegh.2020.04.006

(37) Altaye KZ, Mondal S, Legesse K, Abdulkedir M. Effects of aerobic exercise on thyroid hormonal change responses among adolescents with intellectual disabilities. BMJ Open Sport Exerc Med. 2019;5(1):e000524. https://doi.org/10.1136%2Fbmjsem-2019-000524

(38) Fathi M, Mosaferi Ziaaldini M, Khairabadi S, Hejazi K. Effect of aerobic exercise on thyroid hormones and quality of life in obese postmenopausal women. Medical Laboratory Journal 2018;12(6):5-11. http://dx.doi.org/10.29252/mlj.12.6.5

(39) Krotkiewski M, Sjöström L, Sullivan L, Lundberg PA, Lindstedt G, Wetterqvist H, et al. The effect of acute and chronic exercise on thyroid hormones in obesity. Acta Med Scand. 1984;216(3):269-75. https://doi.org/10.1111/j.0954-6820.1984.tb03804.x

(40) Onsori, M, Galedari, M. Effects of 12 weeks aerobic exercise on plasma level of TSH and thyroid hormones in sedentary women. Euro J Sports Exerc Sci [Internet]. 2015;4(1):45-9. Available from: https://www.researchgate.net/publication/319591512_Effects_of_12_weeks_aerobic_exercise_on_plasma_level_of_TSH_and_thyroid_hormones_in_sedentary_women

(41) Sullo A, Brizzi G, Maffulli N. Deiodinating activity in the brown adipose tissue of rats following short cold exposure after strenuous exercise. Physiol Behav. 2003;80(2-3):399-403. https://doi.org/10.1016/j.physbeh.2003.09.005

Published

09/06/2023

Issue

Section

Original Articles

How to Cite

1.
Gayar SLE. Effect of aerobic training on depression and thyroid function in treated hypothyroid women. Rev Pesq Fisio [Internet]. 2023 Sep. 6 [cited 2024 Dec. 22];13:e5254. Available from: https://www5.bahiana.edu.br/index.php/fisioterapia/article/view/5254

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>