Platelet aggregation and its use in odontology
DOI:
https://doi.org/10.17267/2596-3368dentistry.v12i2.3377Keywords:
Platelet-Rich Plasma. Platelet-Rich Fibrin. Dentistry.Abstract
Tissue repair is an attribute of the organism for healing an injury, recovering the affected tissue. Fibrin plays an important role in the tissue regeneration process. It is defined as a fibrous protein that acts in blood coagulation, promoting platelet aggregation in hemostasis. Some platelet aggregates have been used in odontology to improve the tissue regeneration process: Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF). This work aims to analyze, through literature review, the properties of platelet aggregates, especially on PRF and its use in odontology. The first generation of autologous platelet aggregates was named Platelet-Rich Plasm. Although it was widely used in the first years of its development, some studies have pointed out limitations related to its use due to the protocols used. So, a PRF has been proposed, a second-generation aggregate that has been increasingly used in odontology, mostly in periodontics, surgery, and implantology. According to this review, it can be concluded that PRF may be a material to be chosen when faster and satisfactory results are sought for healing in implant dentistry periodontics and dental surgeries in general. Besides this, it is an easily accessible autologous material of low cost. However, because it is a relatively new technique, further studies are necessary to support its applications.
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Tortora GJ, Derrickson B. Principios de Anatomia e fisiologia. Rio de Janeiro: Guanabara Koogan; 2016. p. 146-65.
Tortora GJ, Derrickson B. Principios de Anatomia e fisiologia. Rio de Janeiro: Guanabara Koogan; 2016. p. 665-91.
Consolaro A. Inflamação e reparo: um sílabo para a compreensão clínica e implicações terapêuticas. Maringá: Dental Press; 2015. p. 252-7.
Ehrenfest DMD, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158-67. https://doi.org/10.1016/j.tibtech.2008.11.009
Tatullo M, Marrelli M, Paduano F. The Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Innovations in the Clinical Application of Mesenchymal Stem Cells. Int J Med Sci. 2015;12(1):72-7. https://doi.org/10.7150/ijms.10706
Marx RE. Platelet-Rich Plasma: Evidence to Support Its Use. J Oral Maxillofac Surg. 2004;62(4):489-96. https://doi.org/10.1016/j.joms.2003.12.003
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37-44. https://doi.org/10.1016/j.tripleo.2005.07.008
Choukroun J, Miron RJ. Platelet Rich Fibrin in Regenerative Dentistry. Oxford: Wiley-Blackwell; 2017. p. 1-14.
Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638-46. https://doi.org/10.1016/j.tripleo.2005.07.008
Marx RE. Platelet-Rich Plasma (PRP): What Is PRP and What Is Not PRP? Implant Dent. 2001;10(4):225-8. https://doi.org/10.1097/00008505-200110000-00002
Amable PR, Carias RB, Teixeira MV, Pacheco IC, Amaral RJC, Granjeiro JM, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4(3):67. https://doi.org/10.1186/scrt218
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3):e56-60. https://doi.org/10.1016/j.tripleo.2005.07.011
Ehrenfest DMD, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun's platelet rich fibrin clot and membrane. J Periodontol. 2010; 81(4):546-55. https://doi.org/10.1902/jop.2009.090531
Mourão CFAB, Valiense H, Melo ERM, Mourão NBMF, Maia MDC. Obtenção da fibrina rica em plaquetas injetável (i-PRF) e sua polimerização com enxerto ósseo: nota técnica. Rev Col Bras Cir. 2015;42(6):421-3. https://doi.org/10.1590/0100-69912015006013
Chang YC, Zhao JH. Effects of platelet rich fibrin on human periodontal ligament fibroblasts and application for period ntal infrabony defects. Aust Dent J. 2011;56(4):365-71. https://doi.org/10.1111/j.1834-7819.2011.01362.x
Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, et al. Platelet rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodontal Res. 2012; 47(4):409-17. https://doi.org/10.1111/j.1600-0765.2011.01446.x
Verma U, Yadav R, Dixit M, Gupta A. Platelet-rich fibrin: A paradigm in periodontal therapy. J Int Soc Prev Community Dent. 2017;7(5):227-33. https://doi.org/10.4103/jispcd.jispcd_429_16
Jeong SM, Lee CU, Son JS, Oh JH, Fang Y, Choi BH. Simultaneous sinus lift and implantation using platelet-rich fibrin as sole grafting material. J Craniomaxillofac Surg. 2014;42(6):990-4. https://doi.org/10.1016/j.jcms.2014.01.021
Mourão CFA, Mourão NBMF. Platelet-rich fibrin membrane in immediate dental implant loading. Dental Press Implantol [Internet]. 2015;9(1):104-9. Disponível em:
Öncü E, Kaymaz E. Assessment of the effectiveness of platelet rich fibrin in the treatment of Schneiderian membrane perforation. Clin Implant Dent Relat Res. 2017;19(6):1009-14. https://doi.org/10.1111/cid.12528
Ozgul O, Senses F, Er N, Tekin U, Tuz HH, Alkan A, et al. Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: randomized multicenter split-mouth clinical trial. Head Face Med. 2015;26;11:37. https://doi.org/10.1186/s13005-015-0094-5
Marenzi G, Riccitiello F, Tia M, di Lauro A, Sammartino G. Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study. Biomed Res Int. 2015;2015:369273. https://doi.org/10.1155/2015/369273
Zhang Y, Ruan Z, Shen M, Tan L, Huang W, Wang L, et al. Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction. Exp Ther Med. 2018;15(3):2277-86. https://dx.doi.org/10.3892%2Fetm.2018.5696
Bakhtiar H, Esmaeili S, Tabatabayi SF, Ellini MR, Nekoofar MH, Dummer PM. Second-generation Platelet Concentrate (Platlet-rich Fibrin) as a Scaffold in Regenerative Endodontics: A Case Series. J Endod. 2017;43(3):401-8. https://doi.org/10.1016/j.joen.2016.10.016
Sharma S, Grover S, Dudeja P, Sharma V, Passi D. Non-Surgical Management of Teeth with Wide Open Apices and Large Periapical Lesions: A Conservative Reality. J Clin Diagn Res. 2016;10(11):ZJ01–2. https://doi.org/10.7860/jcdr/2016/21520.8765
Prasad J, Ataide IN, Chalakkal P, Likhyani LK. Comparison between the Outcomes of Two Platelet-Rich Concentrates on Apexogenesis in Young Permanent Incisors Requiring Endodontic Retreatment. Contemp Clin Dent. 2018; 9(Suppl 1): S156–9. https://doi.org/10.4103/ccd.ccd_9_18
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Copyright (c) 2021 Laize Emanuelle da Silva Alves
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
