Hydroxychloroquine and chloroquine for COVID-19 infection. Rapid systematic review

Authors

  • Rafael Leite Pacheco Universidade Federal de São Paulo (Unifesp); Centro Universitário São Camilo.
  • Rachel Riera Núcleo de Avaliação de Tecnologias em Saúde, Hospital Sírio-Libanês (NATS/HSL); Universidade Federal de São Paulo (Unifesp).

DOI:

https://doi.org/10.17267/2675-021Xevidence.v2i1.2843

Keywords:

COVID-19. SARS-CoV-2. Coronavirus. Hydroxychloroquine. Chloroquine. Systematic review.

Abstract

CONTEXT: Based on the results of preliminary studies, the off-label use of hydroxychloroquine for COVID-19 infection has been observed in practice. OBJECTIVES: To identify, systematically assess and summarize the best available evidence on the efficacy and safety of the use of hydroxychloroquine and chloroquine for COVID-19 infection. METHODS: Rapid systematic review. RESULTS: After the selection process, 30 studies were included: one open-label randomized trial, one open-label non-randomized trial and 28 ongoing studies. The outcome 'detection of viral load in oral swab' (surrogate outcome) was evaluated by both studies, involving a total of 72 participants. The findings of the studies were discordant: one study observed a higher frequency of negative viral load associated with hydroxychloroquine on day-7, while the other study did not observe any difference between hydroxychloroquine and the control group (standard treatment) on day-6. Both studies have methodological limitations when evaluated by specific tools according to study design (Cochrane Bias Risk Table and ROBINS-I). CONCLUSION: This rapid systematic review identified two clinical studies (with available data), with limited methodological quality, that evaluated the effects of hydroxychloroquine for COVID-19 infection. Based on the findings of these two studies, the efficacy and safety of hydroxychloroquine and chloroquine in patients with COVID-19 is still uncertain (very low evidence certainty) and its routine use for this situation should not be recommended until the results of ongoing studies could provide a proper assessment of their effects.

Downloads

Download data is not yet available.

Downloads

Published

2020-03-31

How to Cite

Pacheco, R. L., & Riera, R. (2020). Hydroxychloroquine and chloroquine for COVID-19 infection. Rapid systematic review. Journal of Evidence-Based Healthcare, 2(1), 74–92. https://doi.org/10.17267/2675-021Xevidence.v2i1.2843

Issue

Section

Systematic Reviews

Most read articles by the same author(s)